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TM_Iconc2.png (Technologia Meccanica Logo)J40-J50-J70 Series Fluid Jet Micronizers by Tecnologica Meccanica 
J-40, J-50 & J-70 Series
 

 

Fluid jet micronizers designed for 'small production'

Jet mill systems are the ideal choice for micronising pharmaceutical powders down to 1 micron in size.

Especially developed for pharmaceutical applications, the J-40, J-50 & J-70 Fluid Jet Micronizers are designed for R & D and small production.


Based on the intuitive and highly efficient jet milling technology developed by Tecnologica Meccanica (Italy), the J-40, J-50 & J-70 series of Fluid Jet Micronizers are capable of yielding extremely narrow tight particle size distribution (PSD) curves of d100<5µm (100% below 5µm) and d99<3µm (99% below 3µm) or even less depending on the nature of the product.

 

 

Profile

The J-40 fluid jet micronizer has been designed on the basis of cGMP principles to mainly work with several types of pharmaceutical and food products. The plant is not foreseen to work with flammable products or products that can generate explosive atmospheres.

The J-40 works at a constant temperature (endothermic) and independently with just a nitrogen bottle. It can be installed in ambient conditions without explosion risks (non classified zones).  The unit is also built to be readily assembled/disassembled and easily cleaned with most common detergents and alcohols.  Furthermore, it offers a very high degree of resistance to powder penetration.

Thanks to its modular design concept, the standard J-40 can be upgraded, on request, to the J-50 or J-70 micronizing chambers with very few extra components.

These enhanced versions have wider micronizing characteristics. With these “bigger” milling chambers it is possible to obtain narrower Particle Size Distribution (PSD), or more productivity with the same lab equipment.

Features

•Productivity from 0.05 to 7.00 kg/hour
•One single collecting point bin, available in many different sizes
•Scalability of the process to bigger micronizers
•Very low product loss, typical yields are 99% of batch size
•Elimination of blow-back phenomenon
•Limited caking of sticky powders
•Quick and easy assembling and disassembling of the system with a limited number of clamped components
•Rapid cleaning and easy validation
•Simplicity of the whole unit
•Equipped with a skid-mounted 'Process Gas Generator' for feeding treated gas to the jet mill
•Every equipment is manufactured in AISI type 316L (EN 1.4404) stainless steel or in Hastelloy mirror polished to Ra 0.25 micron
•Special internal lining, Ptfe, Pur (Vulkollan), Ceramic, Titanium nitride, etc.

Benefits

Ability to micronize very small batches/samples from 50 grams up to 7 kg/hour (J-70 model) for small production capacities with an extremely narrow Particle Size Distribution (PSD) of D99<3 micron. This is the main strength/innovation of the these machines.

Thanks to their modular design concept, these micronizers can be used for R&D as well as for small production with max. batch sizes of about 30 Kg.  These mills can very easily allow production of delicate molecules with high yields, requiring a significantly reduced amount of process gas supply to operate.

These compact and versatile units make micronization a much easier process with a low cost of operation and give your laboratory independence from third service contractors for the micronization process.  This family of micronizers has the lowest consumption of process gas compared to similarly sized units available on the market.

Technical Specifications

Milling Chamber: J-40 
  •Process gas at 7 bar=0.45 m3/min (15.9 CFM)
  •Process gas at 12 bar=0.73 m3/min (25.8 CFM)
  •Estimated capacity=from 0.05 to 2.00 kg/hour

Milling Chamber: J-50 
  •Process gas at 7 bar=0.45 m3/min (15.9 CFM)
  •Process gas at 12 bar=0.73 m3/min (25.8 CFM)
  •Estimated capacity=from 0.05 to 5.00 kg/hour

Milling Chamber: J-70 
  •Process gas at 7 bar=0.59 m3/min (20.9 CFM)
  •Process gas at 12 bar=1.01 m3/min (35.7 CFM)
  •Estimated capacity=from 0.25 to 7.00 kg/hour

Options

Numerous configurations are available and can be offered to tailor our micronizers to your specific application(s).  Try your custom version, and our engineering team will work with you in order to develop your personal system.

The following options are already available:
•Many different models of screw feeders
•Many different models of bag filters
•Automatic shaking system for filter sleeve
•Balance line
J-40, J-50 & J-70 milling chambers
J-40, J-50 & J-70 with mini double screw feeders
J-40, J-50 & J-70 with DS50-PH double screw feeder
J-40, J-50 & J-70-LE (low emission version with Hepa filter)
J-40, J-50 & J-70-CRYO (Cold/cryogenic gas process version)
•Explosion proof (ATEX) version
•Sterile version
•Totally contained 'solution in a glove box'

The Standard Pharma Version:
•Modular components that can be shared by all the different milling chambers
•Open manifold execution, FDA validated
•Upper and lower plates + central nozzles ring closed by three handles, or by a single V-clamp
•From 1 lt to 5 lt product collecting bin, depending on the milling chamber
•Polyester anti-static filter sleeve in a stainless steel tube with cylindrical inspection glass
•Supporting table with two pressure gauges, one thermometer and two ball valves
•Manual shaking system
•Anti static swivel castors

Gallery
See it in Action!
Click to download in FLV format (3.31MB)

Find out more about Micronization Technology and its advantages to your applications below:

What is Micronization Technology?

Micronization Technology is a term that refers to the complex process of producing highly-refined powders by properly reducing the size of ordinary powder particles to dimensions below 10 micrometers.

Generally, this is a complicated and rather expensive process with wide applications in various fields, particularly in the pharmaceutical industry where the production of certain drugs, such as inhalers, requires the correct Particle Size Distribution (PSD) for inhaled APIs.

How Does Micronization Technology Work?

Process powder is fed tangentially at subsonic speeds (approximately 50 m/s) into the flat cylindrical milling chamber of the the fluid jet micronizer through a Venturi system using pressurized air or nitrogen.  Once inside the milling chamber, powder particles are then accelerated to supersonic speeds (300 m/s) in a spiral movement by a series of jets around the perimeter of the micronizer.

Click to download in FLV format (565.31kB)

The micronizing effect occurs when the slower incoming powder particles and the faster particles in the spiral path collide.  While centrifugal force retains the larger particles at the periphery of the milling chamber, the smaller particles exit with the exhaust gas from the center of the chamber.

Watch the micronization effect in a jet mill below:

Click to download in FLV format (1.06MB)

This process works at a constant temperature (endothermic) and independently with the lowest consumption of process gas of similarly sized units available on the market.

The Particle Size Distribution (PSD) is controlled by adjusting two main parameters:
PRESSURE: The energy used to micronize; increased pressure increases the micronization effect.
FEED RATE: The concentration of product fed into the milling chamber; the greater the feed rate, the less the micronization effect.  This is due to the fact that particles must have space to achieve proper acceleration before collision occurs.

The Fluid Jet Micronizer Advantages

• Enhanced hi-tech milling chamber geometry
• Nozzles designed for laminar jet streams and available with different grinding angles
• Optimized static classifier
• Elimination of the "caking" of sticky powders
• Narrow Gauss curve (particle size distribution)
• Lowest gas consumption on the market
• Elimination of the "blowback" phenomenon
• Optimised gas-solid separation and unique collecting point with yields close to 100%
• Balance and control of pressures within the whole micronisation system
• Reduction of contact surfaces – rapid cleaning and lower product loss
• Easy cleaning and validation operations
• Sterilizing system with hydrogen peroxide solution
• Inexpensive and easy to operate
• Capable of processing products with high solvent content (around 3000 ppm)
• Capable of processing sticky powders that do not flow well

Find Your Fluid Jet Micronizer Solution

Tecnologia Meccanica has over 40 years experience with Micronization Technology.  It currently manufactures 10 different sizes of Fluid Jet Micronizers, ranging from a capacity of 0.50 to 1500 kg/h, and a throughput of 300-4000 kgs/hr.

Each size caters for a different requirement, depending on your application.  If you are at all unsure or require any help, please do not hesitate to contact us and a technical engineer will be able to assist you.

To browse each solution, simply select your desired model from the available Fluid Jet Mill series list below:

J-20, J-25 & J-30 Series The capacity is from 0.50 g/hour to 100.00 g/hour, suitable for lab and R&D applications. More info

J-40, J-50 & J-70 Series The capacity is from 0.05 to 7.00 kg/hour, suitable for pilot, or small production applications. More info

J-100, J-125 & J-150 Series The capacity is from 0.50 to 30.00 kg/hour, suitable for small production applications. More info

J-200, J-300 & J-400 Series The capacity is from 0.50 to 350.00 kg/hour, suitable for medium to large production applications. More info

J-500, J-600, J-750 & J-900 Series The capacity is from 0.50 to 1500.00 kg/hour, suitable for large production applications. Contact us for more information.



Download Brochure:

pdf-logoJ-40 Data Sheetpdf-logoJ-50 Data Sheetpdf-logoJ-70 Data Sheetpdf-logoJ-40, J-50 & J-70 Product Sheet
pdf-logoJ-40, J-50 & J-70 Presentationpdf-logoFluid Jet Mill Technology 
pdf-logoBenefits From the High-Tech Micronization Processpdf-logoTests and Trials-Fluid Jet Micronizers 
pdf-logoCheck List Sheet-Fluid Jet Micronizerspdf-logoScrew Feederspdf-logoPSD-Fluticasone Propionate

Logo_Tecnologia.jpg (Tecnologia Meccanica Srl)

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